Natural substances: their identification, characterization, optimization, and validation for nutraceutical, cosmeceutical, and pharmaceutical applications

Valorization of naturally-derived molecules through an integrated in silico, in vitro, and in vivo approach

Using an integrated approach, we conduct studies aimed at valorizing bioactive molecules derived from plant matrices, microorganisms (probiotics) or their metabolites (postbiotics) for applications in medicine, nutraceuticals, and cosmetics. Our methodology combines in silico methods with in vitro and in vivo experimental models, thus allowing the characterization of natural bioactive molecules in terms of their impact on biological processes, pharmacological properties, mechanisms of action, and safety.

Metabolomics approaches for the selection, identification, and characterization of natural substances

Metabolomics represents a key tool for the study of natural substances, enabling the analysis of their complex chemical composition and the identification of compounds of interest. The approach combines mass spectrometry with advanced bioinformatics tools to obtain a detailed characterization of the metabolites present in natural extracts. This allows for the selection of the most promising molecules for pharmaceutical, nutraceutical, and cosmetic applications.

Bioprospecting, pathway discovery, and metabolic engineering for the production and valorization of high-value molecules

Bioprospecting, pathway discovery, and metabolic engineering are three interconnected approaches that play a pivotal role in the production and valorization of high-value molecules. Acting synergistically, they represent a powerful biotechnological strategy to elucidate the enzymes and mechanisms underlying the accumulation of molecules in plant species.