Development of advanced multiparametric biological systems and innovative biotechnologies for protection against exogenous hazards

Health impact of environmental factors: focus on air pollution and climate change

To study the toxicological effects of airborne particulate matter (PM 2.5) and ultrafine particles in indoor environments, we adopt an innovative approach combining in vitro and in silico studies. Specifically, exposure of 2D and 3D human lung cells to aerosols under realistic physiological conditions is complemented by molecular dynamics simulations, which allow exploration of the biological effects of airborne particles at the molecular level.

Protection against ionizing radiation: biological dosimetry and assessment of environmental and occupational exposure

The effects of radiation are investigated through an integrated mechanistic approach combining advanced experimental models (in vivo, in vitro, ex vivo) and innovative biotechnologies such as omics approaches. Research covers both the therapeutic use of radiation and radioprotection, with particular attention to oncological diseases of high social impact. Activities include the assessment of individual absorbed doses of ionizing radiation in cases of accidental overexposure (occupational exposure or nuclear incidents) using biological dosimetry methods.

Protection against non‑ionizing radiation: dosimetry and assessment of exposure to electromagnetic fields

The biological effects of exposure to electromagnetic fields are investigated using advanced in silico, in vitro, and in vivo analytical techniques through a multidisciplinary approach that integrates expertise in biology, engineering, and physics. These activities include the development of exposure systems capable of simulating interactions with electromagnetic fields across a wide frequency range, up to 5G millimeter waves (27.5 GHz).