Titolo | Radiation protection and restoration by the synthetic 163-171 nonapeptide of human interleukin 1β |
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Tipo di pubblicazione | Articolo su Rivista peer-reviewed |
Anno di Pubblicazione | 1991 |
Autori | Frasca, D., Baschieri Selene, Boraschi D., Tagliabue A., and Doria G. |
Rivista | Radiation Research |
Volume | 128 |
Paginazione | 43-47 |
ISSN | 00337587 |
Parole chiave | Adjuvants, animal, animal experiment, Animalia, article, comparative study, controlled study, Dose-Response Relationship, Drug, Experimental, Female, human, Immunologic, Interleukin-1, male, Mice, mouse, nonapeptide, Peptide Fragments, priority journal, Radiation Injuries, radiation protection, Radiation-Protective Agents, recombinant interleukin 1, recombinant interleukin 1beta, Recombinant Proteins, whole body radiation |
Abstract | We have previously reported that the synthetic nonapeptide VQGEESNDK, position 163-171 of human interleukin 1 (IL-1β), when injected in immunodepressed mice, shows immunorestorative activity similar to that of the whole protein, but with no IL-1-like inflammatory effects [Frasca et al., J. Immunol. 141, 2651-2655 (1988)]. In the present study we have compared the protective and restorative activities of the nonapeptide and human recombinant (hur) IL-1β on the survival of lethally irradiated mice. When mice were given a single injection of different doses of the nonapeptide or hurIL-1β 20 h before total-body irradiation, both molecules increased the percentage survival of mice exposed to 750 or 850 cGy, but not to 950 cGy. The nonapeptide, however, is less effective than hurIL-1β and displays a different dose-response relationship, suggesting that the two molecules act through different radioprotective pathways. When mice were injected with the nonapeptide or hurIL-1β immediately after exposure to 850 cGy, the percentage survival was also increased but restoration was lower than protection in both cases. The nonapeptide was also less effective than hurIL-1β in restoration, but the two molecules displayed a comparable dose-response relationship as if they shared similar mechanisms. These findings indicate that the 163-171 nonapeptide is able to protect from lethal radiation injury and to restore viability. The nonapeptide appears less effective than hurIL-1β but does not exhibit the IL-1-like side effects of the whole molecule. |
Note | cited By 7 |
URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025951920&partnerID=40&md5=dea01b30db9f0d105193853215097207 |
Citation Key | Frasca199143 |