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Effect of in vivo hyperthermia on thymocyte maturation and selection

TitleEffect of in vivo hyperthermia on thymocyte maturation and selection
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication1992
AuthorsMansoor, S., Spanò M., Baschieri Selene, Cividalli A., Mosiello Lucia, and Doria G.
JournalInternational Immunology
Volume4
Pagination227-232
ISSN09538178
Keywordsanimal, animal cell, animal experiment, animal tissue, article, CD4 antigen, CD8 antigen, cell death, Fever, Flow cytometry, heat shock protein, Hyperthermia, leukocyte count, Lymphocyte Subsets, male, Mice, mitosis, mouse, Non-U.S. Gov't, nonhuman, priority journal, Support, thymocyte, Thymus Gland, Time Factors
Abstract

Two-month-old male mice were exposed to whole-body hyperthermic treatment in a circulating water bath. After 1 h exposure to 41 °C, mice were kept at room temperature for 24, 48, 72, and 96 h before thymus examination. The total thymocyte number progressively decreased after 24 and 48 h, reached a minimum value at 72 h, and returned to almost normal value after 96 h. Similar changes occurred in the CD4+CD8+ cell subset. Conversely, the percentage of CD4-CD8-cells rose to a maximum at 48 h and then declined to normal value at 96 h. The percentage of CD4-CD8+ and CD4+CD8 cell subsets increased to a maximum at 48 h and then declined to normal value at 96 h. These variations in single positive cell subsets correlated well with similar changes in the thymocyte mitotic response to concanavalin A. The observed effects on thymocytes were heat dose dependent, and suggest that hyperthermia induces the development of the most primitive thymocytes and positively selects mature T cells with high mitotic responsiveness. It is proposed that heat shock proteins might be Involved In the hyperthermia-induced alterations of thymocyte maturation and selection. © 1992, Oxford University Press. All rights reserved.

Notes

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0026528865&doi=10.1093%2fintimm%2f4.2.227&partnerID=40&md5=9fa2da94fd2fd42b22073b4fb6862b28
DOI10.1093/intimm/4.2.227
Citation KeyMansoor1992227