| Title | A biodistribution study of two differently shaped plant virus nanoparticles reveals new peculiar traits |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2016 |
| Authors | Lico, Chiara, Giardullo Paola, Mancuso Mariateresa, Benvenuto Eugenio, Santi L., and Baschieri Selene |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume | 148 |
| Pagination | 431-439 |
| ISSN | 09277765 |
| Keywords | animal, Animals, Antibodies, biocompatibility, biodegradability, Biodistributions, blood, Brain, electron, ELISA, Female, Fruits, gene vector, Genetic Vectors, genetics, Genome, immunohistochemistry, immunology, kidney, Liver, lung, Medical applications, metabolism, Mice, Microscopy, mouse, nanoparticle, Nanoparticles, pharmacokinetics, physiology, plant virus, Potato virus X, Potexvirus, Spleen, time factor, Time Factors, Tissue Distribution, Tobacco, Tomato bushy stunt virus, Tombusvirus, Transmission, Transmission electron microscopy, Ultrastructure, Viral, Virion, Virology, virus antibody, Virus Diseases, virus genome, virus infection, Viruses |
| Abstract | Self-assembling plant virus nanoparticles (pVNPs) have started to be explored as nanometre-sized objects for biomedical applications, such as vaccine or drug delivery and imaging. Plant VNPs may be ideal tools in terms of biocompatibility and biodegradability endowed with a wide diversity of symmetries and dimensions, easy chemical/biological engineering, and rapid production in plants. Recently, we defined that icosahedral Tomato bushy stunt virus (TBSV) and filamentous Potato virus X (PVX) are neither toxic nor teratogenic. We report here the results of an interdisciplinary study aimed to define for the first time the biodistribution of unlabelled, unpegylated, underivatized TBSV and PVX by proved detecting antibodies. These data add new insights on the in vivo behaviour of these nano-objects and demonstrate that the pVNPs under scrutiny are each intrinsically endowed with peculiar properties foreshadowing different applications in molecular medicine. © 2016 Elsevier B.V. |
| Notes | cited By 0 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988019845&doi=10.1016%2fj.colsurfb.2016.09.019&partnerID=40&md5=83af5262bcbcad240acde3fa4b095c95 |
| DOI | 10.1016/j.colsurfb.2016.09.019 |
| Citation Key | Lico2016431 |
