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A Microdosimetric Study of Electropulsation on Multiple Realistically Shaped Cells: Effect of Neighbours

TitleA Microdosimetric Study of Electropulsation on Multiple Realistically Shaped Cells: Effect of Neighbours
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2016
AuthorsDenzi, A., Camera Francesca, Merla Caterina, Benassi Barbara, Consales Claudia, Paffi A., Apollonio F., and Liberti M.
JournalJournal of Membrane Biology
Volume249
Pagination691-701
ISSN00222631
Keywordsarticle, cell density, cell membrane potential, Cell Nucleus, cell shape, controlled study, culture medium, dosimetry, human, human cell, measurement accuracy, mesodosimetry, microdosimetry, neuroblastoma cell line, predictive value, pulsed electric field
Abstract

Over the past decades, the effects of ultrashort-pulsed electric fields have been used to investigate their action in many medical applications (e.g. cancer, gene electrotransfer, drug delivery, electrofusion). Promising aspects of these pulses has led to several in vitro and in vivo experiments to clarify their action. Since the basic mechanisms of these pulses have not yet been fully clarified, scientific interest has focused on the development of numerical models at different levels of complexity: atomic (molecular dynamic simulations), microscopic (microdosimetry) and macroscopic (dosimetry). The aim of this work is to demonstrate that, in order to predict results at the cellular level, an accurate microdosimetry model is needed using a realistic cell shape, and with their position and packaging (cell density) characterised inside the medium. © 2016, Springer Science+Business Media New York.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84975137655&doi=10.1007%2fs00232-016-9912-3&partnerID=40&md5=23f9718eeed32d84efaba362eea273a4
DOI10.1007/s00232-016-9912-3
Citation KeyDenzi2016691