Title | In vivo responses of CD4+ and CD8+ cells to bacterial superantigens. |
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Publication Type | Articolo su Rivista peer-reviewed |
Year of Publication | 1992 |
Authors | Herrmann, T, Baschieri Selene, Lees R K., and MacDonald H R. |
Journal | European journal of immunology |
Volume | 22 |
Pagination | 1935-8 |
Date Published | 1992 Jul |
ISSN | 0014-2980 |
Keywords | Animals, Antigens, Bacterial, CD4, CD8, Cytotoxicity, Enterotoxins, Immunologic, Inbred BALB C, lymphocyte activation, Lymphokines, Mice, T-Lymphocytes |
Abstract | Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds to major histocompatibility complex (MHC) class II molecules and specifically activates T cells bearing V beta 8 T cell receptor domains. We have compared several aspects of the response of CD4+ and CD8+ T cell subsets to SEB in vivo. V beta 8+ cells in both subsets proliferated to a similar extent upon SEB injection. Furthermore, mRNA for interferon-gamma was induced in both subsets with similar kinetics and SEB dose-response. Finally CD8+ (but not CD4+) T cells from SEB-injected mice exhibited SEB-specific lysis of MHC class II-bearing target cells. Collectively, these data indicate that the CD4: MHC class II interaction confers no detectable selective advantage to CD4+ cells in the in vivo response to SEB. The observed effector functions of both subsets may contribute to SEB-induced immunopathology. |
Notes | cited By 89 |
URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026681191&doi=10.1002%2feji.1830220739&partnerID=40&md5=638edcf8b0ec56ba2954b064cfb2bfb0 |
DOI | 10.1002/eji.1830220739 |
Citation Key | 5421 |