| Title | Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines. |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 1993 |
| Authors | Baschieri, Selene, Lees R K., Lussow A R., and MacDonald H R. |
| Journal | European journal of immunology |
| Volume | 23 |
| Pagination | 2661-6 |
| Date Published | 1993 Oct |
| ISSN | 0014-2980 |
| Keywords | alpha-beta, Animals, antigen, Antigens, CD4-Positive T-Lymphocytes, CD8, Enterotoxins, Gene expression, Immune Tolerance, Inbred BALB C, Lymphokines, Mice, Receptors, Staphylococcus aureus, Superantigens, T-Cell, T-Lymphocyte Subsets |
| Abstract | Injection of bacterial superantigens such as staphylococcal enterotoxin B (SEB) in adult mice results in initial proliferation of SEB-responsive V beta 8+ T cells followed by induction of a state of non-responsiveness frequently referred to as clonal anergy. We show here that SEB-induced anergy involves selective changes in lymphokine production and that it affects CD4+ V beta 8+ and CD8+ V beta 8+ T cells in different fashions. Whereas both CD4+ V beta 8+ and CD8+ V beta 8+ cells from anergic mice exhibit strongly reduced proliferative capacity and interleukin(IL)-2 production upon restimulation with SEB either in vivo or in vitro the CD8+ subset from SEB-injected mice produces other lymphokines (such as interferon(IFN)-gamma) at normal or slightly increased levels in response to SEB. Changes in the levels of production of IL-2 and IFN-gamma protein correlated well with mRNA accumulation both in vivo and in vitro. Collectively these data suggest that superantigen-induced anergy involves selective changes in signal transduction and/or gene regulation in T lymphocytes. |
| Notes | cited By 62 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027524870&doi=10.1002%2feji.1830231041&partnerID=40&md5=8a430045ef99884b39b0c79ed0a2f426 |
| DOI | 10.1002/eji.1830231041 |
| Citation Key | 5419 |
