The use of Unmanned Aerial Systems allows to exploit the aerial photogrammetry technique to obtain high-resolution orthophotos with large images, owing to latest generation payloads. This approach allows to acquire metric data of a structure through the analysis of pairs of stereometric frames. Aerial photogrammetry forms the basis for the creation of point cloud data models used to develop real-time digital replication of objects (or Digital Twins systems)to monitor, analyze and simulate their behavior in the real world, along with Finite Element models for structural analysis, material simulation and design of complex components. In addition, BIM models are developed that integrate detailed information on infrastructure geometry, materials, and performance into a single collaborative 3D model, for improved management and planning during the bridge lifespan. The results obtained by applying these techniques to an Italian bridge will be examined, providing crucial support to experts in infrastructure assessment and monitoring. © 2024 The Author(s).